发明授权
US07893267B2 Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors
有权
苯并唑衍生物，组合物和作为分泌酶抑制剂的方法
- 专利标题： Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors
- 专利标题（中）： 苯并唑衍生物，组合物和作为分泌酶抑制剂的方法
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申请号： US11885096申请日： 2006-03-14
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公开(公告)号： US07893267B2公开(公告)日： 2011-02-22
- 发明人: Adnan M. M. Mjalli , David Jones , Devi Reddy Gohimmukkula , Guoxiang Huang , Jeff Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
- 申请人： Adnan M. M. Mjalli , David Jones , Devi Reddy Gohimmukkula , Guoxiang Huang , Jeff Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
- 申请人地址： US NC High Point
- 专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人地址： US NC High Point
- 代理商 Robert S. Dailey
- 国际申请： PCT/US2006/009049 WO 20060314
- 国际公布： WO2006/099379 WO 20060921
- 主分类号： C07D217/12
- IPC分类号： C07D217/12 ; A61K31/47
摘要：
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
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