A multiple cylinder internal combustion engine having an engine block with first and second cylinder banks arranged at an angle and longitudinally offset relative to one another and a camshaft disposed within the engine block for actuating valves associated with each cylinder includes first and second cylinder heads associated with the first and second cylinder banks and having an intake runner for each cylinder with an entrance disposed on an outward side, and an exhaust runner for each cylinder exiting the cylinder head on an inward side of the cylinder head generally rearward of an associated cylinder to facilitate positioning of one or more turbochargers and a fuel pump in the valley generally between the cylinder heads with the fuel pump disposed forward of the exhaust runner exits and associated exhaust manifolds while accommodating four valves per cylinder actuated by four pushrods extending through the cylinder heads forward of corresponding exhaust runner exits.