A physiologic data acquisition system includes an analog input, a sigma-delta front end signal conditioning circuit adapted to subtract out DC and low frequency interfering signals from and amplify the analog input before analog to digital conversion. The system can be programmed to acquire a selected physiologic signal, e.g., a physiologic signal characteristic of or originating from a particular biological tissue. The physiologic data acquisition system may include a network interface modulating a plurality of subcarriers with respective portions of an acquired physiologic signal. A receiver coupled to the network interface can receive physiologic data from, and send control signals and provide power to the physiologic data acquisition system over a single pair of wires. The network interface can modulate an RF carrier with the plurality of modulated subcarriers and transmit the resulting signal to the receiver across a wireless network. An integrated circuit may include the physiologic data acquisition system. Also included are methods for acquiring physiologic data comprising the step of selectively controlling an acquisition circuit to acquire the physiologic signal.