发明授权
US07902185B2 Treatment of neurodegenerative diseases using proteasome modulators
失效
使用蛋白酶体调节剂治疗神经变性疾病
- 专利标题： Treatment of neurodegenerative diseases using proteasome modulators
- 专利标题（中）： 使用蛋白酶体调节剂治疗神经变性疾病
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申请号： US10453912申请日： 2003-06-03
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公开(公告)号： US07902185B2公开(公告)日： 2011-03-08
- 发明人: Tennore M. Ramesh , Sean Scott
- 申请人： Tennore M. Ramesh , Sean Scott
- 申请人地址： US MA Cambridge
- 专利权人： ALS Therapy Development Foundation, Inc.
- 当前专利权人： ALS Therapy Development Foundation, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Nutter McClennen & Fish LLP
- 代理商 Thomas J. Engellenner
- 主分类号： A01N43/62
- IPC分类号： A01N43/62 ; A01N43/04 ; A61K31/55 ; A61K31/70
摘要：
Methods for modulating proteasome activity in a subject is provided. Proteasome activity is modulated by administering a therapeutically effective amount of proteasome modulating pharmacological agent to a subject. In a preferred embodiment, the proteasome modulating pharmacological agent is a protease inhibitor. In another aspect, a screening assay for detecting and identifying proteasome modulating pharmacological agents to modulate proteasome activity in a subject is also provided.
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