发明授权
- 专利标题: Cyclic amino benzoic acid derivative
- 专利标题(中): 环状氨基苯甲酸衍生物
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申请号: US11659854申请日: 2005-08-11
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公开(公告)号: US07902367B2公开(公告)日: 2011-03-08
- 发明人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- 申请人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- 申请人地址: JP Tokyo
- 专利权人: Kyorin Pharmaceutical Co., Ltd.
- 当前专利权人: Kyorin Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 优先权: JP2004-234603 20040811
- 国际申请: PCT/JP2005/014718 WO 20050811
- 国际公布: WO2006/016637 WO 20060216
- 主分类号: C07D401/00
- IPC分类号: C07D401/00 ; A01N43/40
摘要:
The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds.A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
公开/授权文献
- US20070249580A1 Novel Cyclic Amino Benzoic Acid Derivative 公开/授权日:2007-10-25