发明授权
- 专利标题： Porous photonic crystal with light scattering domains and methods of synthesis and use thereof
- 专利标题（中）： 具有光散射域的多孔光子晶体及其合成和使用方法
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申请号： US11665613申请日： 2005-10-19
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公开(公告)号： US07903239B2公开(公告)日： 2011-03-08
- 发明人: Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
- 申请人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Greer, Burns & Crain Ltd.
- 国际申请： PCT/US2005/037572 WO 20051019
- 国际公布： WO2006/044957 WO 20060427
- 主分类号： G01N1/00
- IPC分类号： G01N1/00
摘要：
The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.
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