发明授权
- 专利标题： Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedures
- 专利标题（中）： 用于鉴定用于体外重组程序的寡核苷酸组的方法
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申请号： US11982405申请日： 2007-10-31
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公开(公告)号： US07904249B2公开(公告)日： 2011-03-08
- 发明人: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
- 申请人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
- 申请人地址： US CA Redwood City
- 专利权人： Codexis Mayflower Holding, LLC
- 当前专利权人： Codexis Mayflower Holding, LLC
- 当前专利权人地址： US CA Redwood City
- 代理机构： Weaver Austin Villeneuve & Sampson LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/48 ; G06G7/58
摘要：
In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination. In certain embodiments, the methods involve inputting amino acid sequence character strings into a digital system and back-translating the amino acid character strings into a plurality of nucleic acid character strings. The nucleic acid character strings are then processed to define and select at least one recombinant nucleic acid for use in identifying one or more oligonucleotides for in vitro recombination.