Invention Grant
- Patent Title: Activation of peptide prodrugs by hK2
- Patent Title (中): 通过hK2激活肽前体药物
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Application No.: US10535351Application Date: 2003-11-18
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Publication No.: US07906477B2Publication Date: 2011-03-15
- Inventor: Samuel R. Denmeade , John T. Isaacs , Hans Lilja
- Applicant: Samuel R. Denmeade , John T. Isaacs , Hans Lilja
- Applicant Address: US TX San Antonio
- Assignee: Genspera, Inc.
- Current Assignee: Genspera, Inc.
- Current Assignee Address: US TX San Antonio
- Agency: 17th Street Legal, PLLC.
- International Application: PCT/US03/36880 WO 20031118
- International Announcement: WO2004/046169 WO 20040603
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/04 ; A61K31/00 ; A61K51/00
Abstract:
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.
Public/Granted literature
- US20060217317A1 Activation of peptide prodrugs by hk2 Public/Granted day:2006-09-28
Information query
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