发明授权
- 专利标题: Substituted thiophene modulators of intracellular calcium
- 专利标题(中): 细胞内钙的取代噻吩调节剂
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申请号: US12548189申请日: 2009-08-26
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公开(公告)号: US07906553B2公开(公告)日: 2011-03-15
- 发明人: Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
- 申请人: Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
- 申请人地址: US CA La Jolla
- 专利权人: CalciMedica, Inc.
- 当前专利权人: CalciMedica, Inc.
- 当前专利权人地址: US CA La Jolla
- 代理机构: Wilson Sonsini Goodrich & Rosati
- 主分类号: A61K31/38
- IPC分类号: A61K31/38
摘要:
Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
公开/授权文献
- US20100261725A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 公开/授权日:2010-10-14
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