发明授权
US07906649B2 Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
有权
氨基环己烷作为二肽基肽酶-IV抑制剂治疗糖尿病
- 专利标题： Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
- 专利标题（中）： 氨基环己烷作为二肽基肽酶-IV抑制剂治疗糖尿病
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申请号： US11920038申请日： 2006-05-19
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公开(公告)号： US07906649B2公开(公告)日： 2011-03-15
- 发明人: Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Ann E. Weber , Jason Cox
- 申请人： Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Ann E. Weber , Jason Cox
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; John C. Todaro
- 国际申请： PCT/US2006/019598 WO 20060519
- 国际公布： WO2006/127530 WO 20061130
- 主分类号： C07D513/02
- IPC分类号： C07D513/02 ; C07D513/00 ; C07D498/00 ; C07D403/02 ; C07D487/02 ; C07D209/44 ; A61K31/425 ; A61K31/42 ; A61K31/415 ; A61K31/40
摘要：
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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