A gradation twin-wire EDM manufacturing system includes a manufacture machine, a wire feeding bobbin set mounted on the manufacture machine, a wire receiving bobbin set mounted on the manufacture machine, a gradation electro-insulated roller mounted on the manufacturing machine, two wires detoured around the wire feeding bobbin set, the gradation electro-insulated roller and the wire receiving bobbin set, a RC electro discharge circuit connected to one wire, and a transistor RC electro discharge circuit connected to another wire. Therefore, only one manufacture process is needed for a quick manufacture of a workpiece, and thus saving the manufacturing time and enhancing the efficiency.