发明授权
- 专利标题： Interleukin-13 binding proteins
- 专利标题（中）： 白细胞介素-13结合蛋白
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申请号： US11899819申请日： 2007-09-07
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公开(公告)号： US07915388B2公开(公告)日： 2011-03-29
- 发明人: Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
- 申请人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 代理机构： Yankwich & Associates, P.C.
- 代理商 Kenneth Zwicker; Stephen J. Gaudet
- 主分类号： C12P21/08
- IPC分类号： C12P21/08
摘要：
The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
公开/授权文献
- US20080171014A1 Interleukin-13 binding proteins 公开/授权日：2008-07-17
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