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US07919465B2 Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand 有权
抑制血小板受体和血小板受体配体之间相互作用的肽模拟表位

Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand
Abstract:
It is provided mimotope receptors and inhibitors that employ peptide mimics that mimic the shape and function of natural receptors and ligands, thus providing synthetic binding sites for ligands and receptors. Receptor mimics can be attached to carriers, such as liposomes, to act as synthetic platelets, for example, by providing multiple binding sites for binding to other (natural or synthetic) platelets or to the endothelium. Synthetic platelets would have virtually limitless shelf life and would not require disease screening prior to transfusion, thereby providing a solution to the perpetual platelet shortages, as well as the safety and storage issues associated with natural blood platelets.
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