Invention Grant
US07919465B2 Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand
有权
抑制血小板受体和血小板受体配体之间相互作用的肽模拟表位
- Patent Title: Peptide mimotopes that inhibits interaction between a platelet receptor and a platelet receptor ligand
- Patent Title (中): 抑制血小板受体和血小板受体配体之间相互作用的肽模拟表位
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Application No.: US12546811Application Date: 2009-08-25
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Publication No.: US07919465B2Publication Date: 2011-04-05
- Inventor: Maria I. C. Gyongyossy-Issa , Dana V. Devine , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
- Applicant: Maria I. C. Gyongyossy-Issa , Dana V. Devine , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
- Applicant Address: CA Vancouver, BC CA Vancouver, BC CA Vancouver, BC CA Richmond, BC JP Sendai
- Assignee: Maria I. C. Gyongyossy-Issa,Dana V. Devine,Iren Constantinescu,William Campbell,Carlos A. Del Carpio Mundoz
- Current Assignee: Maria I. C. Gyongyossy-Issa,Dana V. Devine,Iren Constantinescu,William Campbell,Carlos A. Del Carpio Mundoz
- Current Assignee Address: CA Vancouver, BC CA Vancouver, BC CA Vancouver, BC CA Richmond, BC JP Sendai
- Agency: Ogilvy Renault LLP
- Main IPC: A61K38/10
- IPC: A61K38/10

Abstract:
It is provided mimotope receptors and inhibitors that employ peptide mimics that mimic the shape and function of natural receptors and ligands, thus providing synthetic binding sites for ligands and receptors. Receptor mimics can be attached to carriers, such as liposomes, to act as synthetic platelets, for example, by providing multiple binding sites for binding to other (natural or synthetic) platelets or to the endothelium. Synthetic platelets would have virtually limitless shelf life and would not require disease screening prior to transfusion, thereby providing a solution to the perpetual platelet shortages, as well as the safety and storage issues associated with natural blood platelets.
Public/Granted literature
- US20100075908A1 MIMOTOPE RECEPTORS AND INHIBITORS FOR PLATELET-PLATELET AND PLATELET-ENDOTHELIUM INTERACTIONS Public/Granted day:2010-03-25
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