发明授权
US07919496B2 Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
失效
用于治疗由硬脂酰辅酶A去饱和酶介导的疾病的杂环衍生物
- 专利标题： Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
- 专利标题（中）： 用于治疗由硬脂酰辅酶A去饱和酶介导的疾病的杂环衍生物
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申请号： US11575636申请日： 2005-09-20
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公开(公告)号： US07919496B2公开(公告)日： 2011-04-05
- 发明人: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
- 申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
- 申请人地址： CA Burnaby
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： CA Burnaby
- 代理机构： Seed IP Law Group PLLC
- 代理商 Thong N. Trinh
- 国际申请： PCT/US2005/033744 WO 20050920
- 国际公布： WO2006/034315 WO 20060330
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D271/113 ; C07D285/135 ; A61K31/50 ; A61K31/415 ; C07D237/20 ; C07D237/24 ; C07D231/38 ; C07D277/42
摘要：
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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