发明授权
US07923556B2 Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
有权
可用作激酶抑制剂的苯基取代的嘧啶化合物
- 专利标题： Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
- 专利标题（中）： 可用作激酶抑制剂的苯基取代的嘧啶化合物
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申请号： US12570010申请日： 2009-09-30
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公开(公告)号： US07923556B2公开(公告)日： 2011-04-12
- 发明人: Stephen T. Wrobleski , Shuqun Lin , Katerina Leftheris , Liqi He , Steven P. Seitz , Tai-An Lin , Wayne Vaccaro
- 申请人： Stephen T. Wrobleski , Shuqun Lin , Katerina Leftheris , Liqi He , Steven P. Seitz , Tai-An Lin , Wayne Vaccaro
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Lauralee L. Duncan
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D403/14 ; A61K31/506 ; A61P19/02 ; A61K31/53 ; C07D401/04 ; C07D401/14
摘要：
Compounds having the formula (I), and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein: two of X1, X2, and X3 are N, and the remaining one of X1, X2, and X3 is —CR1; R1 is hydrogen or —CN; and N, G, Z, R2, R3, R4, R5, and R6 are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase.
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