An acceleration/deceleration control method of a CNC machine tool includes receiving an acceleration/deceleration timing signal and a velocity signal. The acceleration/deceleration timing signal is calculated to acquire a plurality of different first weight values and different second weight values by a first formula and a second formula. A velocity variation of the velocity signal is determined to be zero, positive or negative. The velocity signal is acquired, if the velocity variation is zero. A plurality of acceleration signals are acquired by the velocity signal multiplying each of the first weight values, if the velocity variable is positive. A plurality of deceleration signals are acquired by the velocity signal multiplying each of the second weight values, if the velocity variation is negative. The velocity signal, the acceleration signal and the deceleration signal are converted into a first driving signal, a second driving signal and a third driving signal.