The present invention discloses a method of editing a multi-media playing schedule for a digital photo frame, a system and a computer readable storage medium thereof, which are characterized in that users can edit a multi-media playing schedule on the data processing apparatus when the digital photo frame is electrically connected to the data processing apparatus, and after editing of the multi-media playing schedule is finished, the multi-media playing schedule is transmitted to the digital photo frame and stored in the digital photo frame. Therefore, the problem of being unable to edit complicated multi-media playing schedules due to simple operation interface of digital photo frames can be solved.