发明授权
US07927832B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
失效
涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
- 专利标题： Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
- 专利标题（中）： 涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
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申请号： US12132565申请日： 2008-06-03
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公开(公告)号： US07927832B2公开(公告)日： 2011-04-19
- 发明人: John C. Reed , Matsuzawa Shu-ichi
- 申请人： John C. Reed , Matsuzawa Shu-ichi
- 申请人地址： US CA San Diego
- 专利权人： Sanford-Burnham Medical Research Institute
- 当前专利权人： Sanford-Burnham Medical Research Institute
- 当前专利权人地址： US CA San Diego
- 代理机构： Jones Day
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C07H17/00 ; C07K14/00
摘要：
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
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