发明授权
- 专利标题： Fungal cell wall synthesis gene
- 专利标题（中）： 真菌细胞壁合成基因
-
申请号： US11958310申请日： 2007-12-17
-
公开(公告)号： US07928209B2公开(公告)日： 2011-04-19
- 发明人: Kappei Tsukahara , Katsura Hata , Koji Sagane , Kazutaka Nakamoto , Mamiko Tsuchiya , Naoaki Watanabe , Fuminori Ohba , Itaru Tsukada , Norihiro Ueda , Keigo Tanaka , Junko Kai
- 申请人： Kappei Tsukahara , Katsura Hata , Koji Sagane , Kazutaka Nakamoto , Mamiko Tsuchiya , Naoaki Watanabe , Fuminori Ohba , Itaru Tsukada , Norihiro Ueda , Keigo Tanaka , Junko Kai
- 申请人地址： JP Tokyo
- 专利权人： Eisai R & D Management Co. Ltd.
- 当前专利权人： Eisai R & D Management Co. Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Kilpatrick Townsend and Stockton LLP
- 优先权： JP2000-206968 20000707; JP2000-316027 20001017
- 主分类号： C12N15/80
- IPC分类号： C12N15/80 ; A61K36/06 ; A61K38/00
摘要：
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, fungal genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. These genes encode proteins participating in fungal cell wall synthesis. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
公开/授权文献
- US20080166765A1 FUNGAL CELL WALL SYNTHESIS GENE 公开/授权日：2008-07-10