发明授权
US07932044B2 Identification of non-small cell lung carcinoma (NSCLC) tumors expressing PDGFR-α
有权
鉴定表达PDGFR-α的非小细胞肺癌（NSCLC）肿瘤
- 专利标题： Identification of non-small cell lung carcinoma (NSCLC) tumors expressing PDGFR-α
- 专利标题（中）： 鉴定表达PDGFR-α的非小细胞肺癌（NSCLC）肿瘤
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申请号： US11174051申请日： 2005-07-01
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公开(公告)号： US07932044B2公开(公告)日： 2011-04-26
- 发明人: Klarisa Rikova , Roberto Polakiewicz , Ailan Guo , Katherine Crosby , Qingfu Zeng , Kimberly Lee
- 申请人： Klarisa Rikova , Roberto Polakiewicz , Ailan Guo , Katherine Crosby , Qingfu Zeng , Kimberly Lee
- 申请人地址： US MA Danvers
- 专利权人： Cell Signaling Technology, Inc.
- 当前专利权人： Cell Signaling Technology, Inc.
- 当前专利权人地址： US MA Danvers
- 代理商 Nancy Chiu Wilker
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/574 ; C12Q1/68
摘要：
The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.
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