Invention Grant
US07932077B2 High eicosapentaenoic acid producing strains of Yarrowia lipolytica
有权
高二十碳五烯酸生产的解脂耶氏酵母菌株
- Patent Title: High eicosapentaenoic acid producing strains of Yarrowia lipolytica
- Patent Title (中): 高二十碳五烯酸生产的解脂耶氏酵母菌株
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Application No.: US11265761Application Date: 2005-11-02
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Publication No.: US07932077B2Publication Date: 2011-04-26
- Inventor: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- Applicant: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- Applicant Address: US DE Wilmington
- Assignee: E. I. du Pont de Nemours and Company
- Current Assignee: E. I. du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Main IPC: C12N1/16
- IPC: C12N1/16 ; C12N9/02 ; C12N9/08 ; C12P7/64 ; C07H21/04
Abstract:
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
Public/Granted literature
- US20060115881A1 High eicosapentaenoic acid producing strains of Yarrowia lipolytica Public/Granted day:2006-06-01
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