Invention Grant
US07932421B2 N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
失效
N-环己基苯甲酰胺和苯乙酰胺作为11-β-羟基类固醇脱氢酶的抑制剂
- Patent Title: N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
- Patent Title (中): N-环己基苯甲酰胺和苯乙酰胺作为11-β-羟基类固醇脱氢酶的抑制剂
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Application No.: US12000447Application Date: 2007-12-12
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Publication No.: US07932421B2Publication Date: 2011-04-26
- Inventor: Chester Chenguang Yuan , Nianhe Han , Qingyian Liu , Dustin McMinn , Jay Powers
- Applicant: Chester Chenguang Yuan , Nianhe Han , Qingyian Liu , Dustin McMinn , Jay Powers
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- Main IPC: C07C233/00
- IPC: C07C233/00
Abstract:
The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11β-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
Public/Granted literature
- US20080221175A1 N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases Public/Granted day:2008-09-11
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