A mitigation enablement module for a computer that improves application reliability. When performing memory management operations, the mitigation enablement module and associated memory manager selectively use mitigations that are intended to prevent an application bug from cause an application error. The memory manager may selectively apply mitigations for each of one or more applications based on the likelihood that such mitigations are successful at preventing bugs from causing application errors. The likelihood is determined from historical information on whether the mitigations, when applied, prevented bugs from causing memory operations that could cause application errors. This historical information can be gathered on a single computer over multiple invocations of the application or may be aggregated from multiple computers, each invoking the application. The determined likelihood may then be used to determine whether or for how long to apply the mitigation actions for memory operations requested by the application.