Invention Grant
- Patent Title: siRNA microbicides for preventing and treating diseases
- Patent Title (中): 用于预防和治疗疾病的siRNA杀微生物剂
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Application No.: US11916334Application Date: 2006-06-05
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Publication No.: US07943589B2Publication Date: 2011-05-17
- Inventor: Judy Lieberman , Deborah Palliser , David Knipe
- Applicant: Judy Lieberman , Deborah Palliser , David Knipe
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,Immune Disease Institute, Inc.
- Current Assignee: President and Fellows of Harvard College,Immune Disease Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2006/021758 WO 20060605
- International Announcement: WO2006/133099 WO 20061214
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C07H21/02 ; C12Q1/68
Abstract:
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.
Public/Granted literature
- US20090022783A1 siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES Public/Granted day:2009-01-22
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