发明授权
US07943649B2 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
有权
2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂
![2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/docs/US/2011-05-17/US07943649B2/abs.jpg.600x600.jpg)
- 专利标题： 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
- 专利标题（中）： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂
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申请号： US12288947申请日： 2008-10-24
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公开(公告)号： US07943649B2公开(公告)日： 2011-05-17
- 发明人: Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
- 申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
- 申请人地址： CA Quebec
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： CA Quebec
- 代理商 Valerie J. Camara; Maria V. Marucci
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; A61K31/5377 ; C07D235/02 ; C07D413/14
![2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors](/abs-image/US/2011/05/17/US07943649B2/abs.jpg.150x150.jpg)
摘要：
The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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