发明授权
- 专利标题： Crystalline forms of an 8-azabicyclo(3.2.1)octane compound
- 专利标题（中）： 8-氮杂双环（3.2.1）辛烷化合物的结晶形式
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申请号： US12072534申请日： 2008-02-27
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公开(公告)号： US07943772B2公开(公告)日： 2011-05-17
- 发明人: Sean Dalziel , Leticia M. Preza , Miroslav Rapta , Pierre-Jean Colson
- 申请人： Sean Dalziel , Leticia M. Preza , Miroslav Rapta , Pierre-Jean Colson
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Roberta P. Saxon
- 主分类号： C07D221/02
- IPC分类号： C07D221/02
摘要：
The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamideor a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
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