An apparatus and a method for mitigating interference of a neighbor cell in a multihop relay wireless communication system are provided. The method includes constituting a subframe for a link affected by interference of a neighbor cell over a first frequency band of the frame, and constituting a subframe for a link causing interference to a neighbor cell over a second frequency band of the frame. Therefore, the interference between the neighbor cells can be reduced and the amount of the resources allocated to the links can be freely adjusted.