发明授权
- 专利标题： Protease-resistant modified SEB and vaccine containing the same
- 专利标题（中）： 蛋白酶抗性修饰SEB和含有相同的疫苗
-
申请号： US12644952申请日： 2009-12-22
-
公开(公告)号： US07947290B2公开(公告)日： 2011-05-24
- 发明人: Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
- 申请人： Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
- 申请人地址： JP Kumamoto-shi JP Nagoya-shi
- 专利权人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute,Kowa Company, Ltd.
- 当前专利权人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute,Kowa Company, Ltd.
- 当前专利权人地址： JP Kumamoto-shi JP Nagoya-shi
- 代理机构： Browdy and Neimark, PLLC
- 优先权： JP2003-314187 20030905
- 主分类号： A61K39/085
- IPC分类号： A61K39/085 ; A61K39/09 ; C07K1/00 ; C07K14/00 ; C07K17/00
摘要：
A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.
公开/授权文献
信息查询
