发明授权
US07947466B2 Methods for identifying agents that modulate LGIC receptor activity
有权
鉴定调节LGIC受体活性的试剂的方法
- 专利标题： Methods for identifying agents that modulate LGIC receptor activity
- 专利标题（中）： 鉴定调节LGIC受体活性的试剂的方法
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申请号： US10938370申请日： 2004-09-11
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公开(公告)号： US07947466B2公开(公告)日： 2011-05-24
- 发明人: Scott B. Hansen , Palmer Taylor , Zoran Radic
- 申请人： Scott B. Hansen , Palmer Taylor , Zoran Radic
- 代理机构： Workman Nydegger
- 主分类号： G01N33/483
- IPC分类号： G01N33/483 ; G01N33/52
摘要：
Fluorescence based screening assays are provided that allow for the for identification of agents that selectively bind to a ligand-gated ion channel (LGIC) such as a nicotinic acetylcholine receptor (nAChR). Also provided are methods for identifying agents that selectively bind to a neuronal-type nAChR by detecting binding of the agent to an Aplysia AChBP, which is representative of a neuronal-type nAChR. In addition, compositions and kits for performing such methods are provided.
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