Invention Grant
- Patent Title: Spirolactam tricyclic CGRP receptor antagonists
- Patent Title (中): 螺内酰胺三环CGRP受体拮抗剂
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Application No.: US12085054Application Date: 2006-11-14
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Publication No.: US07947677B2Publication Date: 2011-05-24
- Inventor: Ian M. Bell , Craig A. Stump , Cory R. Theberge , Steven N. Gallicchio , C. Blair Zartman , Harold G. Selnick
- Applicant: Ian M. Bell , Craig A. Stump , Cory R. Theberge , Steven N. Gallicchio , C. Blair Zartman , Harold G. Selnick
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Gerard M. Devlin; Raynard Yuro
- International Application: PCT/US2006/044181 WO 20061114
- International Announcement: WO2007/061692 WO 20070531
- Main IPC: C07D403/06
- IPC: C07D403/06 ; C07D401/06 ; A61K31/55 ; A61K31/4985 ; A61K31/4355 ; A61K31/395 ; A61P25/06
Abstract:
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, J, K, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20090105219A1 Spirolactam Tricyclic CGRP Receptor Antagonists Public/Granted day:2009-04-23
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