发明授权
- 专利标题： Spirolactam tricyclic CGRP receptor antagonists
- 专利标题（中）： 螺内酰胺三环CGRP受体拮抗剂
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申请号： US12085054申请日： 2006-11-14
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公开(公告)号： US07947677B2公开(公告)日： 2011-05-24
- 发明人: Ian M. Bell , Craig A. Stump , Cory R. Theberge , Steven N. Gallicchio , C. Blair Zartman , Harold G. Selnick
- 申请人： Ian M. Bell , Craig A. Stump , Cory R. Theberge , Steven N. Gallicchio , C. Blair Zartman , Harold G. Selnick
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Gerard M. Devlin; Raynard Yuro
- 国际申请： PCT/US2006/044181 WO 20061114
- 国际公布： WO2007/061692 WO 20070531
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; C07D401/06 ; A61K31/55 ; A61K31/4985 ; A61K31/4355 ; A61K31/395 ; A61P25/06
摘要：
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, J, K, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US20090105219A1 Spirolactam Tricyclic CGRP Receptor Antagonists 公开/授权日：2009-04-23
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