A method for calibrating an initial driving signal for driving an optical pick-up head of an optical disk drive is provided. On one embodiment, said optical disk drive is utilized for reading or writing data on an optical disk, the optical disk comprises a plurality of auto power control areas (APC areas) and a plurality of data areas, and the APC areas and the data areas are interleaved in between. First, in the APC areas, an initial driving signal is used to drive the optical pick-up head to emit laserbeam. A detected level of the laserbeam is then obtained. An update initial driving signal is then calibrated according to the detected level and a target level.