发明授权
US07956061B2 Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
有权
二环嘧啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
- 专利标题： Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
- 专利标题（中）： 二环嘧啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
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申请号： US11793093申请日： 2006-01-18
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公开(公告)号： US07956061B2公开(公告)日： 2011-06-07
- 发明人: Wallace T. Ashton , Charles G. Caldwell , Hong Dong , Ying-Duo Gao , Giovanna Scapin , Ann E. Weber
- 申请人： Wallace T. Ashton , Charles G. Caldwell , Hong Dong , Ying-Duo Gao , Giovanna Scapin , Ann E. Weber
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; John C. Todaro
- 国际申请： PCT/US2006/001660 WO 20060118
- 国际公布： WO2006/078676 WO 20060727
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P3/10
摘要：
The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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