发明授权
- 专利标题: Preparation of platinum (II) complexes
- 专利标题(中): 铂(II)配合物的制备
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申请号: US12162745申请日: 2007-01-30
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公开(公告)号: US07956208B2公开(公告)日: 2011-06-07
- 发明人: Jan Gysbert Hermanus Du Preez
- 申请人: Jan Gysbert Hermanus Du Preez
- 申请人地址: ZA Port Elizabeth
- 专利权人: Platco Technologies (Proprietary) Limited
- 当前专利权人: Platco Technologies (Proprietary) Limited
- 当前专利权人地址: ZA Port Elizabeth
- 代理机构: Morrison & Foerster LLP
- 国际申请: PCT/IB2007/000213 WO 20070130
- 国际公布: WO2007/085957 WO 20070802
- 主分类号: C07F15/00
- IPC分类号: C07F15/00
摘要:
This invention relates a method for the preparation of platinum(II) oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the step of reacting a halogenoplatinum(II) complex containing a neutral monodentate or bidentate ligand with an oxalate in a non-aqueous solvent or a mixed solvent system. The mixed solvent system is solvent mixture containing a non-aqueous solvent and water. According to the present invention, the non-aqueous solvent is an alcohol.
公开/授权文献
- US20090281319A1 PREPARATION OF PLATINUM (II) COMPLEXES 公开/授权日:2009-11-12
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