A detection and response system including a set of algorithms for detecting within a stream of normal computer traffic a subset of (should focus on network traffic eliciting a response) TCP or UDP packets with one IP Source Address (SA) value, one or a few Destination Address (DA) values, and a number exceeding a threshold of distinct Destination Port (DP) values. A lookup mechanism such as a Direct Table and Patricia search tree record and trace sets of packets with one SA and one DA as well as the set of DP values observed for the given SA, DA combination. The detection and response system reports the existence of such a subset and the header values including SA, DA, and multiple DPs of the subset. The detection and response system also includes various administrative responses to reports.