发明授权
- 专利标题： Compositions and methods for topical delivery of oligonucleotides
- 专利标题（中）： 用于局部递送寡核苷酸的组合物和方法
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申请号： US12545778申请日： 2009-08-21
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公开(公告)号： US07964579B2公开(公告)日： 2011-06-21
- 发明人: Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
- 申请人： Rahul C. Mehta , Gregory E. Hardee , Phillip Dan Cook , David J. Ecker , Yali Jennifer Tsai , Michael V. Templin
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Knobbe Martens Olson & Bear—Irvine Office
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K31/70 ; C12Q1/68
摘要：
The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
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