发明授权
US07964615B2 Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the β2 adrenergic receptor
有权
4-(2-氨基-1-羟乙基)苯酚的衍生物作为二肾上腺素能受体的激动剂
- 专利标题: Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the β2 adrenergic receptor
- 专利标题(中): 4-(2-氨基-1-羟乙基)苯酚的衍生物作为二肾上腺素能受体的激动剂
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申请号: US11920561申请日: 2006-05-17
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公开(公告)号: US07964615B2公开(公告)日: 2011-06-21
- 发明人: Carlos Puig Duran , Maria Isabel Crespo Crespo , Julio Cesar Castro Palomino Laria , Silvia Gual Roig , Eloisa Navarro Romero
- 申请人: Carlos Puig Duran , Maria Isabel Crespo Crespo , Julio Cesar Castro Palomino Laria , Silvia Gual Roig , Eloisa Navarro Romero
- 申请人地址: ES Barcelona
- 专利权人: Almirall, S.A.
- 当前专利权人: Almirall, S.A.
- 当前专利权人地址: ES Barcelona
- 代理机构: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 优先权: ES200501229 20050520
- 国际申请: PCT/EP2006/004680 WO 20060517
- 国际公布: WO2006/122788 WO 20061123
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; C07D215/00
摘要:
A compound of formula (I) or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof wherein R1 is a group chosen from —CH2OH and —NHC(O)H; R2 is a hydrogen atom or R1 together with R2 form the group —NH—C(O)—CH═CH—, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is chosen from a hydrogen atom, a halogen atom and groups chosen from —SO—R5, —SO2—R5, —NH—CO—NH2, —CO—NH2, hydantoino, C1-4alkyl, C1-4alkoxy and —SO2NR5R6; R4 is chosen from a hydrogen atom, a halogen atom and a C1-4 alkyl group; R5 is chosen from a C1-4 alkyl group and a C3-8 cycloalkyl group; R6 is independently chosen from a hydrogen atom and a C1-4 alkyl group; n, p and q are independently 0, 1, 2, 3 or 4; m and s are independently 0, 1, 2 or 3; and r is 0, 1 or 2 with the provisos that at least one of m and r is not 0, the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13, and the sum q+r+s is 2, 3, 4, 5 or 6.
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