发明授权
- 专利标题： Inhibitors of Taspase1 protease activity
- 专利标题（中）： 抑制Taspase1蛋白酶活性
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申请号： US11851301申请日： 2007-09-06
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公开(公告)号： US07964700B2公开(公告)日： 2011-06-21
- 发明人: James J. D. Hsieh , Stanley J. Korsmeyer , Emily H. Y. Cheng
- 申请人： James J. D. Hsieh , Stanley J. Korsmeyer , Susan Korsmeyer, legal representative , Emily H. Y. Cheng
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Fish & Richardson P.C.
- 主分类号： C07K4/00
- IPC分类号： C07K4/00
摘要：
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
公开/授权文献
- US20080177034A1 Taspase1 and Methods of Use 公开/授权日：2008-07-24
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