发明授权
US07964706B2 High affinity antibodies against HMGB1 and methods of use thereof
失效
针对HMGB1的高亲和力抗体及其使用方法
- 专利标题: High affinity antibodies against HMGB1 and methods of use thereof
- 专利标题(中): 针对HMGB1的高亲和力抗体及其使用方法
-
申请号: US12094447申请日: 2006-11-27
-
公开(公告)号: US07964706B2公开(公告)日: 2011-06-21
- 发明人: Herren Wu , Changshou Gao , Ling-Ling An , Peter Kiener , Su-Yau Mao , Anthony Coyle , Jane Tian
- 申请人: Herren Wu , Changshou Gao , Ling-Ling An , Peter Kiener , Su-Yau Mao , Anthony Coyle , Jane Tian
- 申请人地址: US MD Gaithersburg
- 专利权人: MedImmune, LLC
- 当前专利权人: MedImmune, LLC
- 当前专利权人地址: US MD Gaithersburg
- 代理机构: Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请: PCT/US2006/061258 WO 20061127
- 国际公布: WO2007/084253 WO 20070726
- 主分类号: C07K16/00
- IPC分类号: C07K16/00
摘要:
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.