Systems, methods, and computer program products for supporting multiple contactless applications using different security keys on a wireless smart device are disclosed. According to one aspect, the subject matter described herein includes a method for supporting multiple contactless applications using different security keys on a wireless smart device. The method includes, at a wireless smart device configured to communicate with a wireless smart device reader, the wireless device including a plurality of contactless applications and a contactless application memory for use by the plurality of contactless applications, initializing a portion of the memory such that access to the portion of memory requires the use of a shared secret key known to the plurality of contactless applications. The method includes reserving the portion of memory for use by one of the plurality of contactless applications by using the shared secret key to set access privileges for the portion of memory such that access to the portion of memory requires the use of a application-specific secret key associated with the one application and not known to the other applications.