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发明授权
US07968081B2 Peptide for diagnosing, preventing and treating atherosclerosis and uses thereof 有权
用于诊断，预防和治疗动脉粥样硬化的肽及其用途

Peptide for diagnosing, preventing and treating atherosclerosis and uses thereof
摘要：
A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide effectively targets atherosclerotic plaques, and binds to IL-4R to thereby exhibit antagonistic effects on IL-4-mediated signaling of cellular inflammatory reaction and survival reaction. The peptide of the present invention can be used for diagnosis of atherosclerosis, prevention and treatment of IL-4-induced inflammatory reaction and prevention and treatment of atherosclerosis which is primarily caused by the inflammatory reaction, as well as for prevention or treatment of atherosclerosis via conjugation with an anti-atherosclerotic drug.
摘要（中）：

用于诊断，预防和治疗动脉粥样硬化的肽及其用途，其包含SEQ ID NO：1或SEQ ID NO：2所示的氨基酸序列及其用途。 该肽有效靶向动脉粥样硬化斑块，并结合IL-4R，从而对IL-4介导的细胞炎症反应和存活反应的信号传导具有拮抗作用。 本发明的肽可用于诊断动脉粥样硬化，预防和治疗IL-4诱导的炎性反应以及主要由炎性反应引起的动脉粥样硬化的预防和治疗，以及预防或治疗动脉粥样硬化通过 与抗动脉粥样硬化药物结合。

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