发明授权
- 专利标题： Methods of modulating SMYD3 for treatment of cancer
- 专利标题（中）： 调节SMYD3治疗癌症的方法
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申请号： US11912860申请日： 2006-06-23
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公开(公告)号： US07968281B2公开(公告)日： 2011-06-28
- 发明人: Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
- 申请人： Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
- 申请人地址： JP Kanagawa
- 专利权人： Oncotherapy Science, Inc.
- 当前专利权人： Oncotherapy Science, Inc.
- 当前专利权人地址： JP Kanagawa
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 国际申请： PCT/JP2006/313038 WO 20060623
- 国际公布： WO2007/004526 WO 20070111
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; G01N33/53
摘要：
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified. N-terminal truncated forms of SMYD3 (alias ZNFN3A1) have higher methylating activity. Lys 824 is a preferred methylation site on the RB1 protein for SMYD3.
公开/授权文献
- US20090191181A1 METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER 公开/授权日：2009-07-30
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