Invention Grant
- Patent Title: Methods of modulating SMYD3 for treatment of cancer
- Patent Title (中): 调节SMYD3治疗癌症的方法
-
Application No.: US11912860Application Date: 2006-06-23
-
Publication No.: US07968281B2Publication Date: 2011-06-28
- Inventor: Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
- Applicant: Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
- Applicant Address: JP Kanagawa
- Assignee: Oncotherapy Science, Inc.
- Current Assignee: Oncotherapy Science, Inc.
- Current Assignee Address: JP Kanagawa
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/JP2006/313038 WO 20060623
- International Announcement: WO2007/004526 WO 20070111
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/53
Abstract:
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified. N-terminal truncated forms of SMYD3 (alias ZNFN3A1) have higher methylating activity. Lys 824 is a preferred methylation site on the RB1 protein for SMYD3.
Public/Granted literature
- US20090191181A1 METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER Public/Granted day:2009-07-30
Information query
