Invention Grant
- Patent Title: In vitro evolution in microfluidic systems
- Patent Title (中): 微流体系统体外进化
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Application No.: US10961695Application Date: 2004-10-08
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Publication No.: US07968287B2Publication Date: 2011-06-28
- Inventor: Andrew Griffiths , David Weitz , Keunho Ahn , Darren R. Link , Jerome Bibette
- Applicant: Andrew Griffiths , David Weitz , Keunho Ahn , Darren R. Link , Jerome Bibette
- Applicant Address: US MA Cambridge
- Assignee: Medical Research Council Harvard University
- Current Assignee: Medical Research Council Harvard University
- Current Assignee Address: US MA Cambridge
- Agency: Brown Rudnick LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
Public/Granted literature
- US20060078888A1 In vitro evolution in microfluidic systems Public/Granted day:2006-04-13
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