发明授权
US07968570B2 Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
有权
异吲哚酮化合物及其作为代谢型谷氨酸受体增强剂的用途
- 专利标题： Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
- 专利标题（中）： 异吲哚酮化合物及其作为代谢型谷氨酸受体增强剂的用途
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申请号： US11659149申请日： 2005-08-12
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公开(公告)号： US07968570B2公开(公告)日： 2011-06-28
- 发明人: Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
- 申请人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
- 申请人地址： SE Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Sodertalje
- 代理商 Kenneth F. Mitchell
- 国际申请： PCT/US2005/028760 WO 20050812
- 国际公布： WO2006/020879 WO 20060223
- 主分类号： A61K31/4409
- IPC分类号： A61K31/4409 ; C07D401/14
摘要：
The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.