发明授权
- 专利标题： Antibodies against vascular endothelial growth factor receptor-1
- 专利标题（中）： 抗血管内皮生长因子受体-1的抗体
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申请号： US11719677申请日： 2005-11-18
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公开(公告)号： US07972596B2公开(公告)日： 2011-07-05
- 发明人: Yan Wu , Danny J. Hicklin , Peter Bohlen
- 申请人： Yan Wu , Danny J. Hicklin , Peter Bohlen
- 申请人地址： US NY New York
- 专利权人： ImClone LLC
- 当前专利权人： ImClone LLC
- 当前专利权人地址： US NY New York
- 代理商 Averie K. Hason
- 国际申请： PCT/US2005/041904 WO 20051118
- 国际公布： WO2006/055809 WO 20060526
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12P21/08 ; C07K16/18 ; C07K16/28
摘要：
Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti -VEGFR-I antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti-VEGFR-I antibodies.