发明授权
US07972836B2 Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline
有权
外消旋4-羟基-1,2,3,4-四氢喹啉的酶学光学拆分方法
- 专利标题： Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline
- 专利标题（中）： 外消旋4-羟基-1,2,3,4-四氢喹啉的酶学光学拆分方法
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申请号： US12083014申请日： 2006-10-04
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公开(公告)号： US07972836B2公开(公告)日： 2011-07-05
- 发明人: Masaki Okamoto , Akira Sakuragi , Muneki Kishida , Yoshikazu Mori
- 申请人： Masaki Okamoto , Akira Sakuragi , Muneki Kishida , Yoshikazu Mori
- 申请人地址： JP Osaka-Shi
- 专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址： JP Osaka-Shi
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： JP2005-290757 20051004
- 国际申请： PCT/JP2006/319836 WO 20061004
- 国际公布： WO2007/040238 WO 20070412
- 主分类号： C12P41/00
- IPC分类号： C12P41/00 ; C12P17/18
摘要：
The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]: [wherein R1 represents a hydrogen atom or a protecting group for amino group.] with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; and if necessary, subjecting the reaction product to solvolysis.
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