发明授权
- 专利标题: Methods for synthesis of encoded libraries
- 专利标题(中): 编码库的合成方法
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申请号: US11015458申请日: 2004-12-17
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公开(公告)号: US07972992B2公开(公告)日: 2011-07-05
- 发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
- 申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
- 申请人地址: US MA Waltham
- 专利权人: Praecis Pharmaceuticals, Inc.
- 当前专利权人: Praecis Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Waltham
- 代理机构: McCarter & English, LLP
- 代理商 Maria Laccotripe Zacharakis; Deborah L. Nagle
- 主分类号: C40B50/00
- IPC分类号: C40B50/00
摘要:
The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
公开/授权文献
- US20050158765A1 Methods for synthesis of encoded libraries 公开/授权日:2005-07-21