Invention Grant
- Patent Title: Transferrin/transferrin receptor-mediated siRNA delivery
- Patent Title (中): 转铁蛋白/转铁蛋白受体介导的siRNA递送
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Application No.: US12244027Application Date: 2008-10-02
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Publication No.: US07973019B1Publication Date: 2011-07-05
- Inventor: Jon E. Chatterton , Abbot F. Clark
- Applicant: Jon E. Chatterton , Abbot F. Clark
- Applicant Address: US TX Fort Worth
- Assignee: Alcon Research, Ltd.
- Current Assignee: Alcon Research, Ltd.
- Current Assignee Address: US TX Fort Worth
- Agent Jason J. Derry
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C07K16/00
Abstract:
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided.
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