发明授权
US07977488B2 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
有权
1-杂环基磺酰基，2-氨基甲基，5-（杂）芳基取代的1-H-吡咯衍生物作为酸分泌抑制剂
- 专利标题： 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
- 专利标题（中）： 1-杂环基磺酰基，2-氨基甲基，5-（杂）芳基取代的1-H-吡咯衍生物作为酸分泌抑制剂
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申请号： US11991307申请日： 2006-08-29
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公开(公告)号： US07977488B2公开(公告)日： 2011-07-12
- 发明人: Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
- 申请人： Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
- 申请人地址： JP Osaka
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 David G. Conlin, Esq.; Elbert Chiang
- 优先权： JP2005-250356 20050830; JP2006-100626 20060331
- 国际申请： PCT/JP2006/317408 WO 20060829
- 国际公布： WO2007/026916 WO 20070308
- 主分类号： C07D401/02
- IPC分类号： C07D401/02
摘要：
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.